The Relationship Between the Cytotoxicity of Kanamycin and Ethacrynic Acid for Mammalian Cells in Vitro and Their Ototoxicity in Vivo
作者： K. E. Fox , R. E. Brummett
DOI: 10.3109/00016487909126389
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摘要: Dose-effect curves for inhibition of growth P388/P mouse lymphoma cells by ethacrynic acid and kanamycin used alone in combination were determined vitro. Ethacrynic was 600 times more potent than combinations the drugs resulted overall additive effects. These results compared with known dose-effect data on ototoxicity these vivo. Kanamycin highly selective its toxicity cochlear hair to cultured cells. The coincident that reported functional biochemical effects cochlea following perilymphatic perfusion drug. potentiation observed ototoxic interaction two vivo not
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