Pharmacokinetics of aminoglycoside antibiotics in blood, inner-ear fluids and tissues and their relationship to ototoxicity.

摘要: This review critically evaluates the literature on aminoglycoside pharmacokinetics in order to answer question how fluid and tissue levels of drugs relate development ototoxic nephrotoxic side effects. We will summarize evidence that: (1) aminoglycosides do not accumulate inner-ear fluids; (2) fluids correlate with potential a drug, (3) selective toxicity cannot be explained by penetration drugs. suggest that studies drug disposition at cellular level after chronic treatment conducted establish whether cell-specific uptake contributes antibiotics. A sequence biochemical events may lead molecular is briefly described.