Calcium oxalate crystal interaction with renal tubular epithelium, mechanism of crystal adhesion and its impact on stone development.
作者： S. R. Khan
DOI: 10.1007/BF00307936
关键词:
摘要: The interaction between renal epithelial cells and calcium oxalate (CaOx) crystals and/or ions plays a critical role in the formation of urinary stones. Epithelial respond to hyperoxaluria presence CaOx kidneys by increased enzymuria internalization crystals. Crystal cell results movement from luminal basolateral side basement membrane. Once beneath epithelium, adhere membrane become anchored inside kidneys. Crystals peripheral collecting duct aggregate with other move through an eroding epithelium papillary surface, furnishing encrustation platform or nidus for future development kidney stone. Thus is essential element stone disease.
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