Prolyl Oligopeptidase, Inositol Phosphate Signalling and Lithium Sensitivity
作者： Adrian J. Harwood
DOI: 10.2174/187152711794653779
关键词:
摘要: Inhibition of prolyl oligopeptidase (PO) elevates inositol phosphate (IP) signalling and reduces cell sensitivity to lithium (Li+). This review discusses recent evidence that shows PO acts via the multiple polyphosphate phosphatase (MIPP) regulate gene expression. As a consequence, inhibition causes both transient, rapid increase in I(1,4,5)P3 long-term elevation IP signalling. pathway is evolutionary conserved, being present social amoeba Dictyostelium human systems, has potential implications for mental health.
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