Is there a role for stool metabolomics in cystic fibrosis
作者： Nadeem O Kaakoush , Russell Pickford , Adam Jaffe , Chee Y Ooi , None
DOI: 10.1111/PED.13063
关键词:
摘要: A number of studies utilizing metabolomics have focused on the pathophysiology cystic fibrosis (CF) lung disease. Here, we performed fecal pancreatic insufficient (PI) and sufficient (PS) children with CF compared them healthy controls (HC). Fecal can differentiate between PS-CF PI-CF. We identified a potential biomarker disease severity or transmembrane conductance regulator function (m/z, 463.247; retention time, 0.570717 min) that discriminates HC versus also lipoyl-GMP as novel inflammatory biomarker, elevation in glycerol 1,2-didodecanoate 3-tetradecanoate may provide clues to pathogenesis intestinal inflammation. For first demonstrate applications CF.
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