Particulate adjuvant and innate immunity: past achievements, present findings, and future prospects.

摘要: Particulates and crystals stimulate the immune system to induce inflammatory responses. Several nanometer- micrometer-sized particulates, such as particle matter 2.5 (PM2.5), diesel particles, sand dust, pulmonary inflammation allergic asthma. Conversely, crystal, sphere, hydrogel forms of aluminum salts (referred “alum”) have been used vaccine adjuvants enhance antibody responses in animals humans. Although most these particulates type-2 vivo, molecular immunological mechanisms action a adjuvant are poorly understood. In this review, recent advances particulate research from standpoint innate discussed.