Nrf2 in health and disease: current and future clinical implications

作者: Othman Al-Sawaf , Tim Clarner , Athanassios Fragoulis , Yuet Wai Kan , Thomas Pufe

DOI: 10.1042/CS20150436

关键词:

摘要: The transcription factor Nrf2 (nuclear erythroid 2-related 2) is a major regulator of oxidative stress defence in the human body. As regulates expression large battery cytoprotective genes, it plays crucial role prevention degenerative disease multiple organs. Thus has been focus research as pharmacological target that could be used for and treatment chronic diseases such sclerosis, kidney or cardiovascular diseases. present review summarizes promising findings from basic shows which Nrf2-targeting therapies are currently being investigated clinical trials agents have already entered practice.

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