Polymorphisms in the TOLLIP Gene Influence Susceptibility to Cutaneous Leishmaniasis Caused by Leishmania guyanensis in the Amazonas State of Brazil.

摘要: Introduction The clinical outcome to Leishmania-infection is determined by the individual adaptive immune T helper cell responses and their interactions with parasitized host cells. An early development of a proinflammatory response (Th1 response) necessary for resolution. The Toll-interacting protein (TOLLIP) regulates human Toll-like receptors signaling pathways down regulating cytokines interleukin-6 (IL-6) tumor necrosis factor alpha (TNF-α) inducing ant-inflammatory cytokine interleukin-10 (IL-10). Polymorphisms in TOLLIP gene are associated infectious diseases. Material Methods polymorphisms rs5743899 rs3750920 were genotyped polymerase chain reaction restriction fragment length polymorphism (RFLP) analysis 631 patients cutaneous leishmaniasis (CL) caused L. guyanensis 530 individuals no history leishmaniasis. Results G alleles more common CL than healthy (P = 2.6 x10-8 ; odds ratio [OR], 1.7 [ 95% confidence interval (CI) 1.4–2.0] P 1.9 OR, 1.6 [95% CI 1.4–1.9] respectively). r2 D’ linkage disequilibrium between two 0.05 0.473 bounds 0.37 0.57 respectively. Conclusion independently an increased risk developing CL.