Genetic variants of tumor necrosis factor-α -308G/A (rs1800629) but not Toll-interacting proteins or vitamin D receptor genes enhances susceptibility and severity of malaria infection

摘要: Susceptibility to malaria infection has been associated with host genetic polymorphisms that differs between groups. We hypothesize Toll-interacting proteins (TOLLIP), vitamin D receptor (VDR) and tumor necrosis factor-α (TNF) genes are significant contributors susceptibility disease severity in Plasmodium falciparum (Pf) infection. Our aim is explore the genomic diversity haplotype frequency of these genes, as well extrapolate possible association markers severity, malaria-infected healthy controls. Genomic DNA samples extracted from blood 107 patients 190 uninfected controls were analyzed, no difference genotypic or allelic frequencies TOLLIP VDR polymorphisms. However, a (p = 2.20E-16) TNF-α (snp rs1800629) polymorphism was found. The preponderance mutant variant among show impaired capacity mount an effective immune response, potentially confirmed by our results. This result calls for analysis clearly delineated uncomplicated versus severe groups, including serum assays, providing basis conclude potential contribution significantly but not genes.