The design of new carbonic anhydrase inhibitors.
作者： Umar F. Mansoor , Xiu-Rong Zhang , G. Michael Blackburn
DOI: 10.1007/978-3-0348-8446-4_22
关键词:
摘要: Soon after the discovery of carbonic anhydrase (CA) (Meldrum and Roughton, 1932) it was shown by Mann Keilin (1940) that certain sulfonamides were specific potent inhibitors this enzyme. Since then various arene-and heteroarene-sulfonamides have been synthesised evaluated (Maren, 1967, 1974) as for possible therapeutic use anticonvulsants (Gray et al., 1957; Gray Rauh, 1967), antiglaucoma agents (Becker, 1954; Friedenwald, 1949), cerebral vasodilators (Barnish 1980; Cross 1978), diuretics Peters Roch-Ramel, 1969).
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