Long-term clinical course of extra-oesophageal manifestations in patients with gastro-oesophageal reflux disease: A prospective follow-up analysis based on the ProGERD study

摘要: Abstract Background Gastro-oesophageal reflux disease can be associated with extra-oesophageal such as chronic cough or laryngeal symptoms. The aim of this study was to analyse the clinical course in a large population gastro-oesophageal and under routine care. Methods ProGERD is prospective multicentre cohort 6215 outpatients disease. At baseline all patients underwent endoscopies were interviewed for Initial standardised treatment esomeprazole up 8 weeks. After 2 years follow-up, symptoms prevalence assessed. A multivariate analysis performed resolved versus persistent dependent predictors. Independent variables gender, age, body mass index (BMI), alcohol consumption, cigarette smoking, classification, history family, duration proton pump inhibitors medication. Results Four thousand four hundred (71%) available at years, including 570 454 who had disorders baseline, respectively. In 63% 74% patients, resolved. Patients respiratory year significantly more Further clinically relevant associations smoking non-steroidal anti-inflammatory drugs use. According analysis, classification disease, medication not resolution Conclusion most resolve during long-term high symptom load persistence disorders.