Review article: respiratory manifestations of gastro‐oesophageal reflux disease

摘要: Summary Background  Respiratory manifestations represent one of the most prevalent and difficult-to-manage extra-oesophageal syndromes gastro-oesophageal reflux disease. Aims  To review epidemiology, pathophysiological mechanisms therapeutic outcomes reflux-related respiratory disorders. Methods  Search literature published in English using PubMed database. Results  There is a discrepancy between high prevalence asthmatics limited efficacy antireflux therapies. Asthma per se may cause reflux. Patients with difficult-to-treat asthma and/or nocturnal symptoms should be screened for Reflux can induce chronic cough through different including micro-aspiration both local central reflexes. Cough precipitate each other. A meta-analysis found no significant difference placebo proton pump inhibitors resolution cough. Encouraging results have been reported, following surgery patients selected on basis pH-impedance monitoring. Attention has drawn to obstructive sleep apnoea syndrome. Conclusions  The role disease pathogenesis miscellaneous disorders discussed decades established However, major advances reported recently. Future trials concentrate patient selection control recently developed technologies, such as