Serum angiotensin converting enzyme activity in sarcoidosis as measured by a simple radiochemical assay.

摘要: A new simple radiochemical assay for serum angiotensin converting enzyme based on the hydrolysis of [glycine-1−14C] hippuryl-L-histidyl-L-leucine was used to quantify convertingenzyme activity in normal control subjects and patients with sarcoidosis. Serum concentrations were significantly higher (P < 0.0005) 42 active sarcoidosis (71.9 ± 19.2 units per ml) compared 60 (40.2 ±8.6 ml). Patients Stage I had a lower 0.05) mean (66.1 16.0 than II or III disease (77.1 21.1 Considering 57 ml (2 SD above value) be “increased,” 33 (79 cent) increased activity, whereas only 3 (5 activity. Seven 9 pat...