6,7-Seco- ent -kaurane-type diterpenoids from Isodon eriocalyx var. laxiflora
作者： Wei-Guang Wang , Bing-Chao Yan , Xiao-Nian Li , Xue Du , Hai-Yan Wu
DOI: 10.1016/J.TET.2014.08.018
关键词:
摘要: Twenty nine 6,7-seco-ent-kaurane-type diterpenoids including 18 new ones, laxiflorolides C-T (1-18), along with 21 known ones were obtained from Isodon eriocalyx var. laxiflora. Laxiflorolides E-G (3-5) are the first identified naturally occurring 6,7-seco-ent-kauranoids that feature a 3,6-epoxy unit, and laxi-florolide M (11) is 6-nor-6,7-seco-ent-kauranoid. The absolute configurations of compounds 1, 3, 6, 11 determined by single-crystal X-ray diffraction analyses. cytotoxic activity isolates was evaluated an MTF assay. (C) 2014 Elsevier Ltd. All rights reserved.
irgrid.ac.cn参考文章(48)
Yoshio TAKEDA, Tetsuro FUJITA, Han-dong SUN, Yoshinori MINAMI, Masamitsu OCHI, Cheng-Chang CHEN, Revision of the Structures of Isodonal, Rabdolasional and Related Diterpenoids Chemical & Pharmaceutical Bulletin. ,vol. 38, pp. 1877- 1880 ,(1990) , 10.1248/CPB.38.1877
Yun-Heng Shen, Zhi-Ying Wen, Gang Xu, Wei-Lie Xiao, Li-Yan Peng, Zhong-Wen Lin, Han-Dong Sun, Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx. Chemistry & Biodiversity. ,vol. 2, pp. 1665- 1672 ,(2005) , 10.1002/CBDV.200590136
Wei Zhao, Wei-Guang Wang, Xiao-Nian Li, Xue Du, Rui Zhan, Juan Zou, Yan Li, Hai-Bo Zhang, Fei He, Jian-Xin Pu, Han-Dong Sun, None, Neoadenoloside A, a highly functionalized diterpene C-glycoside, from Isodon adenolomus Chemical Communications. ,vol. 48, pp. 7723- 7725 ,(2012) , 10.1039/C2CC33656A
Bing-Ji Ma, Chun-Nan Wen, Yuan Gao, Fu-Cai Ren, Fei Wang, Ji-Kai Liu, ent-Kaurane diterpenoids from the plant Wedelia trilobata Natural Products and Bioprospecting. ,vol. 3, pp. 107- 111 ,(2013) , 10.1007/S13659-013-0029-4
Wei-Guang Wang, Xue Du, Xiao-Nian Li, Bing-Chao Yan, Min Zhou, Hai-Yan Wu, Rui Zhan, Ke Dong, Jian-Xin Pu, Han-Dong Sun, Four new diterpenoids from Isodon eriocalyx var. laxiflora Natural Products and Bioprospecting. ,vol. 3, pp. 145- 149 ,(2013) , 10.1007/S13659-013-0057-0
John T.S. Yeoman, Jacob Y. Cha, Victor W. Mak, Sarah E. Reisman, A unified strategy for the synthesis of (−)-maoecrystal Z, (−)-trichorabdal A, and (−)-longikaurin E Tetrahedron. ,vol. 70, pp. 4070- 4088 ,(2014) , 10.1016/J.TET.2014.03.071
Chunyong Ding, Yusong Zhang, Haijun Chen, Zhengduo Yang, Christopher Wild, Na Ye, Corbin D Ester, Ailian Xiong, Mark A White, Qiang Shen, Jia Zhou, None, Oridonin Ring A-Based Diverse Constructions of Enone Functionality: Identification of Novel Dienone Analogues Effective for Highly Aggressive Breast Cancer by Inducing Apoptosis Journal of Medicinal Chemistry. ,vol. 56, pp. 8814- 8825 ,(2013) , 10.1021/JM401248X
Ping Lu, Zhenhua Gu, Armen Zakarian, Total Synthesis of Maoecrystal V: Early-Stage C–H Functionalization and Lactone Assembly by Radical Cyclization Journal of the American Chemical Society. ,vol. 135, pp. 14552- 14555 ,(2013) , 10.1021/JA408231T
John T. S. Yeoman, Victor W. Mak, Sarah E. Reisman, A Unified Strategy to ent-Kauranoid Natural Products: Total Syntheses of (−)-Trichorabdal A and (−)-Longikaurin E Journal of the American Chemical Society. ,vol. 135, pp. 11764- 11767 ,(2013) , 10.1021/JA406599A
E. González-Burgos, M.E. Carretero, M.P. Gómez-Serranillos, Kaurane diterpenes from Sideritis spp. exert a cytoprotective effect against oxidative injury that is associated with modulation of the Nrf2 system Phytochemistry. ,vol. 93, pp. 116- 123 ,(2013) , 10.1016/J.PHYTOCHEM.2013.03.017