Mammary involution and breast cancer risk: transgenic models and clinical studies.

摘要: Postlactational involution is the process following weaning during which mammary gland undergoes massive cell death and tissue remodeling as it returns to pre-pregnant state. Lobular by breast epithelial gradually lost with aging of gland. While postlactational lobular are distinct processes, recent studies have indicated that both related cancer development. Experiments using a variety rodent models, well observations in human populations, suggest deregulation may act facilitate tumor formation. By contrast, new show completion protects against subsequent incidence.