Ancestry as a potential modifier of gene expression in breast tumors from Colombian women

摘要: Author(s): Serrano-Gomez, Silvia J; Sanabria-Salas, Maria Carolina; Garay, Jone; Baddoo, Melody C; Hernandez-Suarez, Gustavo; Mejia, Juan Carlos; Garcia, Oscar; Miele, Lucio; Fejerman, Laura; Zabaleta, Jovanny | Abstract: BackgroundHispanic/Latino populations are a genetically admixed and heterogeneous group, with variable fractions of European, Indigenous American African ancestries. The molecular profile breast cancer has been widely described in non-Hispanic Whites but equivalent knowledge is lacking Hispanic/Latinas. We have previously reported that the most prevalent intrinsic subtype Colombian women was Luminal B as defined by St. Gallen 2013 criteria. In this study we explored ancestry-associated differences profiles tumors among these highly women.MethodsWe performed whole-transcriptome RNA-seq analysis 42 (21 A 21 B) from women. Genetic ancestry estimated panel 80 ancestry-informative markers (AIM). categorized patients according to proportion European differential expression comparing against assigned groups.ResultsWe found 5 genes potentially modulated genetic ancestry: ERBB2 (log2FC = 2.367, padjl0.01), GRB7 2.327, GSDMB 1.723, padjl0.01, MIEN1 2.195, padjl0.01 ONECUT2 2.204, padjl0.01). replication set statistical significant association between (p 0.02, 3.11). This not biased distribution HER2+ groups analyzed.ConclusionsOur results suggest Hispanic/Latina might modify gene tumors. Further analyses needed confirm findings explore their prognostic value.