Resistance to senescence induction and telomere shortening by a G-quadruplex ligand inhibitor of telomerase.

作者: Céline Douarre , Hamid Morjani , Chantal Trentesaux , Kazuo Shin-Ya , Dennis Gomez

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摘要: The molecular mechanisms induced by G-quadruplex ligands to trigger senescence in mammalian cells are still unknown, although the critical role of telomerase is highly suspected. JFA2 selected for resistance ligand 12459 presented an overexpression hTERT transcript that correlated a functional increase activity and telomere length. Consistently, treatment with failed shortening cells. Resistant also cross-resistance induction telomestatin, another from different series, but not other anticancer agents, indicating selectivity mechanism. We, thus, provide evidence length key cellular determinants ligands.

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