The Expected Outcome of the Trypanosoma cruzi Proteomic Map: A Review of Its Potential Biological Applications for Drug Target Discovery

摘要: Chagas disease is a neglected tropical illness endemic to Latin America, and its treatment remains unsatisfactory. This caused by the hemoflagellate protozoan Trypanosoma cruzi, which has complex life cycle involving three evolutive forms in both vertebrate invertebrate hosts. Targeting metabolic pathways parasite for rational drug design represents promising research field. area requires high performance techniques proteomics become powerful tool this context. Here, we review advances construction of proteomic maps different T. emphasizing their biological applications towards identification alternative candidates intervention.