Determining signal transduction pathways
作者： Earl Hubbell , Jonathan D. Oliner
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摘要: Experimental and analytical methods enable reconstruction of signal transduction networks from gene expression profiles. Signal pathways can be reverse-engineered by 1) experimentally manipulating individual genes, 2) generating cellular profiles, 3) analyzing for common patterns among these Analysis profiles permits interrelationships genes their products.
lens.org 参考文章(10)
David H. Mack, Expression monitoring for gene function identification ,(1998)
Stephen H. Friend, Roland Stoughton, Methods for identifying pathways of drug action ,(1999)
Satoru Miyano, Tatsuya Akutsu, Osamu Maruyama, Satoru Kuhara, Identification of gene regulatory networks by strategic gene disruptions and gene overexpressions symposium on discrete algorithms. pp. 695- 702 ,(1998) , 10.5555/314613.315050
Leland H. Hartwell, Patrick O. Brown, Stephen H. Friend, Matthew J. Marton, Joseph L. DeRisi, Holly A. Bennett, Vishwanath R. Iyer, Michael R. Meyer, Christopher J. Roberts, Roland Stoughton, Julja Burchard, David Slade, Hongyue Dai, Douglas E. Bassett, Drug target validation and identification of secondary drug target effects using DNA microarrays Nature Medicine. ,vol. 4, pp. 1293- 1301 ,(1998) , 10.1038/3282
I. Bernard Weinstein, Strategies for inhibiting multistage carcinogenesis based on signal transduction pathways. Mutation Research. ,vol. 202, pp. 413- 420 ,(1988) , 10.1016/0027-5107(88)90202-3
Arul M. Chinnaiyan, Clifford G. Tepper, Michael F. Seldin, Karen O'Rourke, Frank C. Kischkel, Stefan Hellbardt, Peter H. Krammer, Marcus E. Peter, Vishva M. Dixit, FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis Journal of Biological Chemistry. ,vol. 271, pp. 4961- 4965 ,(1996) , 10.1074/JBC.271.9.4961
M. Schena, D. Shalon, R. Heller, A. Chai, P. O. Brown, R. W. Davis, Parallel human genome analysis: microarray-based expression monitoring of 1000 genes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 10614- 10619 ,(1996) , 10.1073/PNAS.93.20.10614
Edwin Southern, Analysing polynucleotide sequences ,(2002)
S J Baker, E P Reddy, Transducers of life and death: TNF receptor superfamily and associated proteins. Oncogene. ,vol. 12, pp. 1- 9 ,(1996)