Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells.
作者： S Gobessi , L Laurenti , P G Longo , L Carsetti , V Berno
DOI: 10.1038/LEU.2008.346
关键词:
摘要: … Recently, Syk was found to be constitutively phosphorylated in several common B-cell … -independent Syk activation in the pathogenesis of these diseases. We now report that Syk is …
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Irene M. Pedersen, Shinichi Kitada, Lorenzo M. Leoni, Juan M. Zapata, James G. Karras, Nobuhiro Tsukada, Thomas J. Kipps, Yong Sung Choi, Frank Bennett, John C. Reed, Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1. Blood. ,vol. 100, pp. 1795- 1801 ,(2002) , 10.1182/BLOOD.V100.5.1795.H81702001795_1795_1801
Shinichi Kitada, Janet Andersen, Sophie Akar, Juan M. Zapata, Shinichi Takayama, Stanislaw Krajewski, Hong-Gang Wang, Xin Zhang, Florencia Bullrich, Carlo M. Croce, Kanti Rai, John Hines, John C. Reed, Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations with in vitro and in vivo chemoresponses Blood. ,vol. 91, pp. 3379- 3389 ,(1998) , 10.1182/BLOOD.V91.9.3379
Stuart M. Lichtman, Philip Schulman, Vincent P. Vinciguerra, Kanti R. Rai, Manlio Ferrarini, Nicholas Chiorazzi, Rajendra N. Damle, Tarun Wasil, Franco Fais, Fabio Ghiotto, Angelo Valetto, Steven L. Allen, Aby Buchbinder, Daniel Budman, Klaus Dittmar, Jonathan Kolitz, Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. ,vol. 94, pp. 1840- 1847 ,(1999) , 10.1182/BLOOD.V94.6.1840
Terry J. Hamblin, Zadie Davis, Anne Gardiner, David G. Oscier, Freda K. Stevenson, Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. ,vol. 94, pp. 1848- 1854 ,(1999) , 10.1182/BLOOD.V94.6.1848
Richard R. Furman, Zahra Asgary, John O. Mascarenhas, Hsiou-Chi Liou, Elaine J. Schattner, Modulation of NF-κB Activity and Apoptosis in Chronic Lymphocytic Leukemia B Cells The Journal of Immunology. ,vol. 164, pp. 2200- 2206 ,(2000) , 10.4049/JIMMUNOL.164.4.2200
Andrea Rinaldi, Ivo Kwee, Monica Taborelli, Cristina Largo, Silvia Uccella, Vittoria Martin, Giulia Poretti, Gianluca Gaidano, Giuseppe Calabrese, Giovanni Martinelli, Luca Baldini, Giancarlo Pruneri, Carlo Capella, Emanuele Zucca, Finbarr E. Cotter, Juan C. Cigudosa, Carlo V. Catapano, Maria G. Tibiletti, Francesco Bertoni, Genomic and expression profiling identifies the B‐cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma British Journal of Haematology. ,vol. 132, pp. 303- 316 ,(2006) , 10.1111/J.1365-2141.2005.05883.X
Hiroaki Niiro, Edward A. Clark, Regulation of B-cell fate by antigen-receptor signals Nature Reviews Immunology. ,vol. 2, pp. 945- 956 ,(2002) , 10.1038/NRI955
Reuben P. Siraganian, Juan Zhang, Teruaki Kimura, Mutations in the activation loop tyrosines of protein tyrosine kinase Syk abrogate intracellular signaling but not kinase activity. Journal of Immunology. ,vol. 161, pp. 4366- 4374 ,(1998)
Murali Gururajan, Trivikram Dasu, Seif Shahidain, C. Darrell Jennings, Darrell A. Robertson, Vivek M. Rangnekar, Subbarao Bondada, Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth. Journal of Immunology. ,vol. 178, pp. 111- 121 ,(2007) , 10.4049/JIMMUNOL.178.1.111
Sebastian Deindl, Theresa A. Kadlecek, Tomas Brdicka, Xiaoxian Cao, Arthur Weiss, John Kuriyan, Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70. Cell. ,vol. 129, pp. 735- 746 ,(2007) , 10.1016/J.CELL.2007.03.039