"True" antiandrogens-selective non-ligand-binding pocket disruptors of androgen receptor-coactivator interactions: novel tools for prostate cancer.
作者： Laura Caboni , Gemma K. Kinsella , Fernando Blanco , Darren Fayne , William N. Jagoe
DOI: 10.1021/JM201438F
关键词:
摘要: … Prostate cancer (PCa) therapy typically involves administration of “classical” antiandrogens, competitive inhibitors of androgen receptor (AR) ligands, dihydrotestosterone (DHT) and …
acs.org
sci-hub.se 参考文章(41)
M E Kaighn, Y Ohnuki, K S Narayan, L W Jones, J F Lechner, Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Investigative urology. ,vol. 17, pp. 16- 23 ,(1979)
Jillian R. Gunther, Alexander A. Parent, John A. Katzenellenbogen, Alternative Inhibition of Androgen Receptor Signaling: Peptidomimetic Pyrimidines As Direct Androgen Receptor/Coactivator Disruptors ACS Chemical Biology. ,vol. 4, pp. 435- 440 ,(2009) , 10.1021/CB900043E
Gerd Hummel, Ulrich Reineke, Ulf Reimer, Translating peptides into small molecules Molecular BioSystems. ,vol. 2, pp. 499- 508 ,(2006) , 10.1039/B611791K
Mary-Ellen Taplin, Judith Manola, William K. Oh, Philip W. Kantoff, Glenn J. Bubley, Matthew Smith, Diana Barb, Christos Mantzoros, Edward P. Gelmann, Steven P. Balk, A Phase II Study of Mifepristone (RU-486) in Castration-Resistant Prostate Cancer, With a Correlative Assessment of Androgen-Related Hormones BJUI. ,vol. 101, pp. 1084- 1089 ,(2008) , 10.1111/J.1464-410X.2008.07509.X
ROBERT J. FLETTERICK, Molecular modelling of the androgen receptor axis: rational basis for androgen receptor intervention in androgen-independent prostate cancer. BJUI. ,vol. 96, pp. 2- 9 ,(2005) , 10.1111/J.1464-410X.2005.05940.X
Peter Axerio-Cilies, Nathan A Lack, M Ravi Shashi Nayana, Ka Hong Chan, Anthony Yeung, Eric Leblanc, Emma S Tomlinson Guns, Paul S Rennie, Artem Cherkasov, None, Inhibitors of Androgen Receptor Activation Function-2 (Af2) Site Identified Through Virtual Screening. Journal of Medicinal Chemistry. ,vol. 54, pp. 6197- 6205 ,(2011) , 10.1021/JM200532B
Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin, Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International Journal of Cancer. ,vol. 127, pp. 2893- 2917 ,(2010) , 10.1002/IJC.25516
R. Michael Sramkoski, Thomas G. Pretlow, Joseph M. Giaconia, Theresa P. Pretlow, Stuart Schwartz, Man-Sun Sy, Susan R. Marengo, Johng S. Rhim, Desheng Zhang, James W. Jacobberger, A new human prostate carcinoma cell line, 22Rv1. In Vitro Cellular & Developmental Biology – Animal. ,vol. 35, pp. 403- 409 ,(1999) , 10.1007/S11626-999-0115-4
Eva EstÉbanez-PerpiñÁ, Natalia Jouravel, Robert J Fletterick, Perspectives on designs of antiandrogens for prostate cancer Expert Opinion on Drug Discovery. ,vol. 2, pp. 1341- 1355 ,(2007) , 10.1517/17460441.2.10.1341
Ji-Hu Zhang, Thomas D. Y. Chung, Kevin R. Oldenburg, A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. Journal of Biomolecular Screening. ,vol. 4, pp. 67- 73 ,(1999) , 10.1177/108705719900400206