Quantification of Particle Residence Time in Abdominal Aortic Aneurysms Using Magnetic Resonance Imaging and Computational Fluid Dynamics

摘要: Hemodynamic conditions are hypothesized to affect the initiation, growth, and rupture of abdominal aortic aneurysms (AAAs), a vascular disease characterized by progressive wall degradation enlargement aorta. This study aims use magnetic resonance imaging (MRI) computational fluid dynamics (CFD) quantify flow stagnation recirculation in eight AAAs computing particle residence time (PRT). Specifically, we used gadolinium-enhanced MR angiography obtain images vessel lumens, which were generate subject-specific models. We also phase-contrast MRI measure blood at supraceliac infrarenal locations prescribe physiologic boundary conditions. CFD was simulate pulsatile flow, PRT, index, half-life PRT computed. observed significant regional differences with localized patterns that differed depending on aneurysm geometry flow. A bulbous lowest mean demonstrated slowest clearance. In addition, improvements clearance increase postulate augmentation during exercise may reduce chronic stasis influence mural thrombus burden, wall, growth.