Supraceliac and Infrarenal Aortic Flow in Patients with Abdominal Aortic Aneurysms: Mean Flows, Waveforms, and Allometric Scaling Relationships

摘要: Purpose Hemodynamic forces are thought to play a critical role in abdominal aortic aneurysm (AAA) growth. In silico and vitro simulations can be used study these forces, but require accurate geometries boundary conditions. Many AAA use patient-specific geometries, utilize inlet conditions taken from single, unrelated, healthy young adult. Methods this study, we imaged 43 patients using 1.5 T MR scanner. A 24-frame cardiac-gated one-component phase-contrast magnetic resonance imaging sequence was measure volumetric flow at the supraceliac (SC) infrarenal (IR) aorta, where information is typically needed for simulation. For first 36 patients, individual waveforms were interpolated 12-mode Fourier curve, peak-aligned, averaged. Allometric scaling equations derived log–log plots of mean SC IR vs. body mass, height, surface area (BSA), fat-free mass. The data last seven validate our model. Results Both averaged had biphasic shapes characteristic older adults, flows over cardiac cycle 51.2 ± 10.3 17.5 5.44 mL/s, respectively. Linear regression revealed that BSA most strongly predictive (R2 = 0.29) 0.19), with highest combined R2. When averaged, measured predicted agreed well. Conclusions We present method estimate