Vaginal and Cervical Abnormalities Related to Prenatal Exposure to Diethylstilbestrol (DES)

摘要: Primary neoplasms of any type are uncommon in the vagina, with malignant forms accounting for less than 2% all cancers female genital tract. The most common cancer is squamous cell carcinoma, which usually occurs elderly women. Clear adenocarcinomas, have also been called mesonephromas and mesonephric carcinomas, much more rare. Prior to 1970 only sporadic cases were known occurred older women four examples had reported young females.12 When seven clear adenocarcinoma vagina unexpectedly encountered at Massachusetts General Hospital between 1966 1969,12 a search factor their medical histories led association these tumors exposure utero diethylstilbestrol (DES), synthetic, nonsteroidal estrogen that administered mothers high-risk pregnancy.15 Later, highly significant but constant cervix prenatal DES became apparent. Nonneoplastic changes tract, including vaginal adenosis cervical erosion, found not great majority patients subsequently high percentage asymptomatic females who exposed prenatally chemically related drugs, hexestrol dienestro1.1,3,5,8–15,25,29,32,33,36