Vaginal and cervical abnormalities after exposure to stilbestrol in utero.

摘要: 34 girls 13-24 years of age whose mothers had taken stilbestrol during pregnancy were studied. Only 1 been pregnant and she delivered a healthy child. 2 inter-mentrual bleeding staining. 32 asymptomatic. Vaginal smears obtained the entire vaginal surface was inspected careful examination made for early neoplasms all red areas vagina biopsied mucosa that did not stain by Schiller technic biopsied. During 11-month study 275 other same but without history intrauterine exposure to also examined. Of those exposed in utero 59 24 cervical biopsy specimens obtained. unexposed group 15 speciments spots 19 patients have biopsies because no abnormality observed. remaining: showed congestion 13 adenosis. The smallest speciment measured sq mm largest 21 with 7 average. In none from adenosis detected. erosion present including 9 cases extensive histology resembled except cervix papillary fronds covered endocervical-type epithelium. 8 chronic inflammation. Squamous metaplasia glands seen 4 cases. Protruding transverse ridges tissue partly or completely encircling upper patients. All No observed any cytology suspicious carcinoma 5 especially 1. 14 who began receive before 12th week pregnancy. therapy continued 3 months throughout constant dose pattern A similar diverse dosage abnormalities. It is suggested may be developmental abnormality. Also never thought congenital origin as are septa. Exposure considered cause. such should Those followed up frequently. 0Clear-cell adenocarcinoma has represent high risk group. However appears small. Symptomatic lesions associated nuclear atypica treated although spontaneous regression