The Clinical Development of Lurtotecan
作者： Keith T. Flaherty , James P. Stevenson , Christopher J. Twelves , Peter J. O’Dwyer
DOI: 10.1385/1-59259-866-8:301
关键词:
摘要: Camptothecin (CPT) derivatives have become integral to the management of lung and colon cancer. They continue be subject intense investigation. The parent compound, CPT, was extracted from leaves Camptotheca acuminata by Wall Wani in 1957. hydrophilic carboxylate salt entered clinical trials late 1960s. lack efficacy unpredictable bone marrow bladder toxicity halted its development (1). When topoisomerase I (TOP-I) discovered as target CPT class compounds 1985 (2), there a resurgence interest compound.
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