Deciphering adipose tissue heterogeneity.

摘要: Obesity is an excess accumulation of adipose tissue mass, and, together with its sequelae, in particular type II diabetes and metabolic syndrome, obesity presents a major health crisis. Although simply caused by increased the heterogeneity humans means that response to energy balance highly complex. Individual subjects similar phenotypes may respond very differently same treatments; therefore, benefit from personalized precision medicine approach. The variability development indeed driven differences sex, genetics, environment, but also various types as well different cell compose it. By describing distinct populations reside fat depots, we can interpret complex effect these players maintenance whole-body homeostasis. To further understand tissue, adipogenic differentiation transcriptional program lipid must be investigated. As cell- depot-specific functions are described, they placed context how shapes individual status condition.