The role of the cowpox virus crmA gene during intratracheal and intradermal infection of C57BL/6 mice

摘要: Abstract Intratracheal (i.t.) infection of mice with cowpox virus (CPXV), is lethal at a lower dose than intranasal (i.n.) inoculation. CPXV deleted for cytokine response modifier A (CPXVΔcrmA) was attenuated compared to after i.t. This attenuation could not be attributed differences in replication, immunomodulators, or cells infiltrating the lungs. Deletion crmA also caused during intradermal (i.d.) infection. In contrast i.t.-inoculated virus, deletion reduced replication site difference correlated increased numbers CD3 + CPXVΔcrmA-associated dermal lesions. Thus, virulence factor either pulmonary infection; however influence more evident i.d. suggests that host immune differs two routes and emphasizes need consider effect route when examining functions factors vivo .