The inflammasome as a target of modulation by DNA viruses.

摘要: The cellular innate immune response represents the initial reaction of a host against infecting pathogens. Host cells detect incoming microbes by way large and expanding array receptors that react with evolutionarily conserved molecular patterns exhibited microbial intruders. These are responsible for initiating signaling leads to both transcriptional activation immunologically important genes as well protease-dependent processing proteins. inflammasome refers protein complex functions an platform cysteine protease caspase-1, which then processes inflammatory molecules such IL-1β IL-18 into functional forms. Assembly this is triggered following receptor-mediated detection pathogen-associated molecules. Receptors have been identified essential in numerous including virus-associated DNA. In fact, importance cytoplasmic DNA stimulus exemplified existence at least nine distinct capable reactivity molecule. Viruses employ genomic material include herpesviruses, poxviruses adenoviruses. Each has described inducing inflammasome-mediated activity. Interestingly, however, these responses appear vary according species, cell type even viral strain. Secretion components antimicrobial immunity and, result, pathogens evolved factors evade or counteract response. This includes DNA-based viruses, many encode multiple redundant counteractive However, it clear phenotypes only beginning be uncovered. purpose review describe what known regarding infection well-examined families viruses discuss characterized mechanisms manipulation neutralization inflammasome-dependent aims shed light on biologically phenomena virus-host interaction highlight key areas where information lacking.