Tumor necrosis factor gene polymorphisms and clearance or progression of hepatitis B virus infection.

摘要: : Objectives: We evaluated the influence of tumor necrosis factor-α (TNF-α) promoter gene polymorphisms on clearance hepatitis B virus (HBV) and outcome HBV chronic hepatitis. Methods: Four TNF-α (T-1031C, C-863A, G-308A, G-238A) were by direct sequencing in 184 carriers surface antigen (HBsAg) positive 96 controls with documented sero-clearance (HBsAg negativity, positivity for anti-HBs anti-HBc IgG). Frequencies single-nucleotide (SNPs) haplotypes control group compared those carrier clinically defined subgroups latter: asymptomatic carriers, patients compensated hepatitis, decompensated cirrhotics, hepatocellular carcinoma. Furthermore, among them. Results: In group, −308G allele was more frequent a family history infection (96% vs 88% non-familial transmission). The G/G genotype at position −308 found all cirrhosis but only 78% (P=0.01) cirrhotics than other subgroups. distribution not significantly different from that group. SNPs positions −1031/−863 −863/−238 linkage disequilibrium. TCGG haplotype (−T1031, −C863, −G308, −G238) associated end-stage liver disease. Conclusion: do appear to be determinant southern Italians. −308G/G are an unfavorable prognosis infection.