Platelet aggregation measurement for assessment of hemostasis failure mechanisms in patients with gastroduodenal ulcer bleeding.

摘要: BACKGROUND The purpose of this study was to identify factors associated with the risk unsustainable hemostasis in patients gastric and duodenal ulcer bleeding by vitro assessment platelet reactivity using artificial neural networks. METHODS Patients gastroduodenal ulcers complicated were studied. Platelet aggregation measured aggregometry adenosine diphosphate 5 μM, epinephrine 2.5 5-hydroxytryptophan 10 collagen 1 thrombin 0.06 NIH Unit/mL as agonists. Multiple logistic regression used evaluate independent relationship between demographic, clinical, endoscopic, laboratory data local parameters bleeding. RESULTS Analysis allowed variability response different agonists effective concentration which induces 50% (EC50) be established. spatial-temporal characteristics demonstrated. Adrenoreactivity platelets time elapsed since start degree hemorrhage. lowest detected active (P < 0.001) recent 0.01). Decreased diphosphate-induced correlated (r = 0.714, P 0.584, CONCLUSION Estimation indicates key mechanisms failure In addition gender, an important determinant a decreased diphosphate.