Comparative genomics and functional analysis of the 936 group of lactococcal Siphoviridae phages

摘要: Genome sequencing and comparative analysis of bacteriophage collections has greatly enhanced our understanding regarding their prevalence, phage-host interactions as well the overall biodiversity genomes. This knowledge is very relevant to phages infecting Lactococcus lactis, since they constitute a significant risk factor for dairy fermentations. Of eighty four lactococcal phage genomes currently available, fifty five belong so-called 936 group, most prevalent ten recognized groups. Here, we report genetic characteristics new collection group phages. By combining these those sequenced previously determined core variable elements genome. Genomic variation occurs across genome, such that (i) lead +1 translational frameshift resulting in formation additional structures on tail, (ii) specify double neck passage structure, (iii) encode packaging module-associated methylases. Hierarchical clustering gene complement nucleotide alignments allowed grouping ninety into distinct clusters, which general appear correspond with geographical origin.