Temporal changes in serum biomarkers and risk for progression of gastric precancerous lesions: a longitudinal study.

摘要: Effectively managing precancerous lesions is crucial to reducing the gastric cancer (GC) burden. We evaluated associations of temporal changes in multiple serological markers (pepsinogen I [PGI], PGII, PGI/II ratio, gastrin-17 and anti-Helicobacter pylori IgG) with risk for progression lesions. From 1997 2011, repeated esophagogastroduodenoscopies mucosal biopsies blood sample collections were conducted on 2,039 participants (5,070 person-visits) Zhuanghe Gastric Diseases Screening Program, Liaoning, China. Serum biomarkers measured using ELISA, standardized histologic criteria. Odds ratios (OR) 95% confidence intervals (CI) estimated generalized estimating equations correlated binary outcomes. The ORs conditions comparing those whose serum PGI, anti-H. IgG levels increased ≥50% relative decreased were, respectively 1.67 (CI, 1.22-2.28), 1.80 1.40-2.33) 1.93 1.48-2.52). OR ratio 50% was 1.40 1.08-1.81), PGII both 3.18 2.05-4.93). Changes not statistically significantly associated progression. These findings suggest that (especially combined) may be useful assessing