Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles.

摘要: Subjects characterized by a predominance of small LDL particles (pattern B) have changes in plasma triglyceride (TG) and HDL-cholesterol concentrations consistent with the presence resistance to insulin-mediated glucose uptake. To pursue this issue, insulin responses oral glucose, disposal, lipoprotein were measured subjects categorized on basis peak diameter gradient gel electrophoresis. pattern B had higher (P < 0.05-0.001) total integrated (20.7 +/- 1.0 mmol/liter.h) (1,743 293 pmol/liter.h) compared (16.3 0.4 19.2 0.8 (856 60 1,222 168 those either A or an intermediate pattern. Pattern individuals shown be more resistant steady state (SSPG, 10.4 1.0, P 0.002, vs. 7.5 0.7 6.0 mmol/liter) after constant infusion somatostatin, than subclass. also 0.001) TG (1.98 0.15 1.33 0.17 0.77 0.05 lower 0.01-0.001) HDL cholesterol (1.12 0.06 1.34 1.45 A. Finally, significant correlation coefficients existed between SSPG (r = -0.44); -0.41) -0.38) responses; -0.65) 0.42) concentrations; systolic -0.34) diastolic blood pressure. Thus, are resistant, insulin, TG, levels, pressure intermediate.