Anti-cord factor (trehalose 6,6'dimycolate) IgG antibody in tuberculosis patients recognizes mycolic acid subclasses.

摘要: The detection of anti-cord factor (trehalose 6,6′-dimycolate) IgG antibody in active (smear-and/or culture-positive) and inactive (smear- culture-negative) tuberculosis patients is a useful serodiagnostic tool that can be used for early clinical diagnosis the disease. We estimated titers anticord sera patients, compared them with those Mycobacterium avium-infected patients. Most serum samples obtained from were highly reactive against M. (MTB) cord isolated H37Rv, human-type mycobacterial strain, whereas they less avium (MAC) factor. Similarly, most MAC-infected MAC MTB These results suggest recognizes mycolic acid subclasses as an epitope which comprises factor, since differ molecular species composition. To clarify exact antigenic to find out more sensitive specific diagnostic test antigen, we examined reactivity patients' glycolipids containing trehalose (cord sulfolipid) various species. Furthermore, human antisera (α-, methoxy keto acids) was compared. found strikingly recognized tuberculosis, it α- acids weakly. Pre-absorption studies or methyl ester showed absorbed partially, but consistently. This first report describing subclass mycobacteria humoral immune system infection.