The Role of Anti-dengue Virus NS-1 and Anti-protein Disulfide Isomerase Antibodies on Platelet Aggregation in Secondary Dengue Infection

摘要: Aim : to observe the correlation between anti-NS-1 and anti PDI antibodies against platelets function disorder on secondary dengue infection. Methods 50 patients with DV infection according WHO criteria were observed by a cross sectional study. Patient’s blood was collected day 3, 5 7 after fever onset. Platelets aggregation test done prove possibility of dysfunction. Anti-NS-1 anti- determined solid phase ELISA. Results inhibition increased among observation. Means value 3 is 46.6%, 52.5% 56%. There significant difference (p 0.05). Conclusion kinetics profile NS1 responses, which detected third symptoms. Dengue patients’ sera inhibited aggregation. NS-1 might have role dysfunction; however, there no them. It possible that other mechanism involve in Key words antibodies, aggregation,