Equilibrium studies of complex formation involving palladium(II)-(1,3-diaminopropane) and cyclobutane dicarboxylic acid, DNA units, amino acids or peptides

作者: Samir M. El-Medani , Shahera M. Shohayeb , Mohamed M. Shoukry

DOI: 10.1023/A:1015712901496

关键词:

摘要: Complex formation equillibria of [Pd(DAP)(H2O)2]2+ (DAP = 1,3-diaminopropane) with Cl−, OH−, cyclobutane dicarboxylic acid (CBDCA), amino acids, peptides and DNA unit constituents have been investigated. Stoichiometries stability constants the complexes were determined at 37°C 0.16 M NaNO3 ionic strength. The results showed 1:1 acids CBDCA. Peptides form both corresponding deprotonated amide species. 1:2 complexes. [Pd(DAP)(CBDCA)] was isolated characterized. concentration distribution in solution evaluated.

参考文章(17)
Patrick J Loehrer, LAWRENCE H EINHORN, Cisplatin Annals of Internal Medicine. ,vol. 100, pp. 704- 713 ,(1984) , 10.7326/0003-4819-100-5-704
E. A. Olman, D. A. Van Echo, A. Forrest, J. Aisner, M. J. Egorin, M. Y. Whitacre, Prospective validation of a pharmacologically based dosing scheme for the cis-diamminedichloroplatinum(II) analogue diamminecyclobutanedicarboxylatoplatinum. Cancer Research. ,vol. 45, pp. 6502- 6506 ,(1985)
Karol Maskos, Spectroscopic studies on the copper(II)—Inosine system Journal of Inorganic Biochemistry. ,vol. 25, pp. 1- 14 ,(1985) , 10.1016/0162-0134(85)83002-6
Mohamed M. Shoukry, Ibrahim M. Kenawy, Ibrahim H. El-Haj, Ternary complexes of palladium(II) and selected amines Transition Metal Chemistry. ,vol. 16, pp. 637- 640 ,(1991) , 10.1007/BF01024206
Bela Noszal, Verena Scheller-Krattiger, R. Bruce Martin, A unified view of carbon bound hydrogen exchange of H(2) in imidazoles and H(8) in purine nucleosides and their metal ion complexes Journal of the American Chemical Society. ,vol. 104, pp. 1078- 1081 ,(1982) , 10.1021/JA00368A027
Mohamed M. Shoukry, Ezzat M. Khairy, Adel Saeed, MIXED-LIGAND COMPLEXES OF PALLADIUM(II) WITH DIETHYLENETRIAMINE Journal of Coordination Chemistry. ,vol. 17, pp. 305- 310 ,(1988) , 10.1080/00958978808073921
Badar Taqui Khan, R. Madhusudhan Raju, S. M. Zakeeruddin, Binary and Ternary Metal Complexes of Uridine and Thermodynamic Quantities Associated with the Interaction of Uridine with Bivalent Metal ions in Solution Journal of Coordination Chemistry. ,vol. 16, pp. 237- 244 ,(1987) , 10.1080/00958978708081207
MohamedM. Shoukry, WafaaM. Hosny, MohamedM. Khalil, Equilibrium and hydrolysis of α-amino acid esters in mixed-ligand complexes withN-(acetamido)-iminodiacetatecopper(II) Transition Metal Chemistry. ,vol. 20, pp. 252- 255 ,(1995) , 10.1007/BF00143487