Intracellular Transport of Fatty Acids in Muscle

摘要: Long-chain fatty acids represent a major substrate for energy production in striated muscles, especially those muscles which have high oxidative enzymatic capacity. Following their uptake from the extracellular compartment to translocate through aqueous cytoplasm of myocytes reach mitochondria where they undergo degradation. This intracellular transport is assisted by cytoplasmic acid-binding protein (FABPc), small (15 kD) shows affinity non-covalent binding long-chain acids, and several types occur. So-called heart-type or muscle-type FABPc found muscle cells, abundant fibers. The muscular content appears relate rate acid utilization, also changes concert modulations utilization induced (patho)physiological stimuli (e. g. endurance training, diabetes). facilitation accomplished increasing concentration diffusing and, most likely, interacting directly with membranes promote transfer cytosolic protein.