Association of the insulin-like growth factor1 gene with myocardial infarction in Japanese subjects.
作者： Noriko Aoi , Tomohiro Nakayama , Masayoshi Soma , Kotoko Kosuge , Akira Haketa
DOI: 10.1111/J.1601-5223.2010.02174.X
关键词:
摘要: During adult life, the insulin/insulin-like growth factor1 (IGF1) signaling pathway plays an important role in cardiovascular function. Several reports have suggested that low baseline levels of IGF1 increase risk fatal ischemic heart disease. Thus, may be involved The aim present study was to investigate relationship between human gene and myocardial infarction (MI) Japanese population via use single nucleotide polymorphisms (SNPs). After selecting six SNPs (rs2162679, rs7956547, rs2288378, rs2072592, rs978458 rs6218), we performed a case-control using each haplotypes 320 MI patients 307 non-MI controls. Multiple logistic regression analysis demonstrated GG+GA variant rs2162679 (p=0.009) AA+GA rs2072592 (p=0.026) exhibited resistant effect for MI. haplotype-based revealed frequency A-T-G-G haplotype rs2162679-rs7956547-rs2072592-rs978458 significantly higher group (47.3%) as compared (41.4%) (p=0.037, odds ratio=1.270). A-T-G-T rs2162679-rs7956547-rs978458-rs6218 also (41.3%) (p=0.033, ratio=1.276). current results suggest specific can utilized genetic markers or resistance. In addition, neighboring might associated with increased decreased susceptibility
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