Diagnostic value of procalcitonin serum levels in comparison with C-reactive protein in allogeneic stem cell transplantation
作者： Karl-Walter Sykora , Elke Dammann , Arnold Ganser , Matthias Eder , Bernd Hertenstein
DOI: 10.3324/%X
关键词:
摘要: BACKGROUND AND OBJECTIVES: Infections represent the major complications following allogeneic stem cell transplantation (SCT). A promising marker for a more specific and early detection of bacterial or fungal infections is procalcitonin (PCT). DESIGN METHODS: Maximum values (m) increase (Delta) PCT C-reactive protein (CRP) were prospectively analyzed during 214 clinical events in cohort 61 patients undergoing SCT. Systemic reactions classified according to ACCP/SCCM criteria. RESULTS: mPCT mCRP (normal 1 microg/L, > 100 mg/L, DeltaPCT microg/L DeltaCRP 50 mg/L. An infection was usually detected day after onset fever, while rise CRP occurred before. strongly correlated with severity systemic reaction (sepsis vs severe sepsis/septic shock: p=0.0002). INTERPRETATION CONCLUSIONS: The diagnostic value not superior that However, assays may be useful studies which compare infectious complications.
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