Teratogenic potential of cocaine hydrochloride in CF-1 mice

作者: Michael P. Mahalik , Ronald F. Gautieri , David E. Mann

DOI: 10.1002/JPS.2600690625

关键词:

摘要: This investigation revealed that cocaine hydrochloride was teratogenic when administered in nontoxic doses to gravid CF-1 mice on Days 7–12 of gestation. The susceptibility the mouse fetus evident throughout this portion gestation period. early appearance eye defects and occurrence skeletal later after challenge paralleled sequence ontogenesis.

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