Gender differences in skeletal muscle substrate metabolism - molecular mechanisms and insulin sensitivity.

摘要: It has become increasingly apparent that substrate metabolism is subject to gender specific regulation, and the aim of this review outline available evidence molecular differences in glucose lipid skeletal muscle. Female sex been suggested have a favorable effect on homeostasis, from hyperinsulinemic-euglycemic clamp studies summarized delineate whether there difference whole body insulin sensitivity particular insulin-stimulated uptake Whether an eventual higher female muscle can be related regulation will topic for discussion. Gender fiber type distribution availability are highly relevant men women. In particular, machinery fatty acid oxidative storage capacities its implications utilization during metabolic situations daily living discussed, emphasizing their relevance choice fed fasted state, periods physical activity recovery. Together, handling carbohydrate lipids homeostasis 17-β estradiol most important hormone, identification receptors opened role metabolism. Also, levels circulating adipokines as adiponectin leptin women considered.