Recent Advance in Chemical and Biological Studies on Cimicifugeae Pharmaceutical Resources

摘要: Abstract Cimicifugeae is one of the rich sources for various active components and health promoting therapeutic values have been corroborated by long-term use in folk medicine traditional Chinese medicine. Increasing interest pharmaceutical resources has led to further discoveries triterpenoid saponins, phenolic compounds, chromones, many other compounds species Cimicifugeae, investigations on their chemotaxonomy, molecular phylogeny, bioactivities. Based our pharmacophylogenetic studies, progress phytochemistry, biology, phylogeny had summarized since 2007, especially Cimicifuga L. ex Wernisch. Actaea L., relevance efficacy. An exhaustive literature survey used characterize global scientific effort phytochemical biological studies Cimicifugeae. More saponins found species, among which cimigenol type (type A) predominant. The versatile bioactivities extracts, as well those phenolics ingredients, were discussed. morphology-based five-genus classification not supported phylogeny. Molecular based nuclear chloroplast DNA sequences tends merge Wernisch., Souliea Franch., into a single genus. It indispensable integrate emerging technologies research both sustainable utilization finding novel with potential clinical utility less adverse effects. Systems biology omics would play an increasingly important role booming involving bioactive