Lorazepam and midazolam in the intensive care unit: a randomized, prospective, multicenter study of hemodynamics, oxygen transport, efficacy, and cost.

摘要: Objectives To evaluate and compare the clinical efficacy, impact on hemodynamic oxygen transport variables, safety profiles, cost efficiency of sedation anxiolysis with lorazepam vs. continuous infusion midazolam in critically ill, intensive care unit patients. Design Multicenter, prospective, randomized, open-label study. Setting Teaching hospitals. Patients Ninety-five mechanically ventilated patients fiberoptic pulmonary artery catheters place were randomly assigned to receive short-term (8 hrs) either intermittent intravenous injection (group A, n = 50) or B, 45) titrated response. Measurements main results The severity illness, demographic characteristics, levels anxiety agitation, parameters, quality sedation, nursing acceptance, laboratory chemistries reflecting drug recorded. There no significant differences regard data, anxiety/agitation between two groups at baseline, 5 mins, 30 4 8 hrs after administration sedation. anxiolysis. Midazolam-treated used significantly larger amounts for similar (14.4 +/- 1.2 mg/8 1.6 0.1 hrs, p .001). Both drugs safely administered patient nurse satisfaction was similar. Conclusions Sedation ill is safe clinically effective. Hemodynamic variables are similarly affected by both drugs. dose required much than therefore less cost-efficient.