Confirmatory assay for the simultaneous detection of five penicillins in muscle, kidney and milk using liquid chromatography?electrospray mass spectrometry
作者： W. John Blanchflower , S. Armstrong Hewitt , D. Glenn Kennedy
DOI: 10.1039/AN9941902595
关键词:
摘要: A confirmatory assay using liquid chromatography–electrospray mass spectrometry (LC–EMS) is presented for the simultaneous determination of penicillins V and G along with oxacillin, cloxacillin dicloxacillin in muscle, kidney milk. Nafcillin used as an internal standard. Samples are extracted acetonitrile cleaned up liquid–liquid extraction into dichloromethane. The extracts injected a dedicated LC–EMS instrument any present detected multiple single-ion monitoring. Three or four ions can be each penicillin, meeting one recommended EU criteria residue analyses low-resolution spectrometry. detection limits below stipulated maximum
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