CML-T1: a cell line derived from T-lymphocyte acute phase of chronic myelogenous leukemia
作者： K Kuriyama , RP Gale , M Tomonaga , S Ikeda , E Yao
DOI: 10.1182/BLOOD.V74.4.1381.1381
关键词:
摘要: Most data suggest that malignant transformation in chronic myelogenous leukemia (CML) occurs hematopoietic stem cell is the progenitor of myelopoiesis and B but not T lymphopoiesis. We established a T-lymphoid line (CML-T1) from person with Ph-chromosome-negative CML acute phase. Evidence its T-lymphocyte origin includes pattern cytochemical reactivity, reactivity anti-T-cell monoclonal antibodies (MoAbs), rearrangement beta-T-cell receptor (TCRB) gene. CML-T1 cells have features type IV thymocytes. Cytogenetic analyses indicate 47,XX, del(11), t(6;7)(q23;q24), +mar karyotype. exhibit molecular changes typical CML, including translocation ABL protooncogene chromosome 9 to 22, BCR gene, transcription chimeric BCR-ABL messenger RNA (mRNA). The insertion on 22 appears interstitial, similar other cases CML. These clearly can be involved acute-phase should useful studying this process as well underlying
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bloodjournal.org参考文章(48)
JD Griffin, R Tantravahi, GP Canellos, JS Wisch, EL Reinherz, G Sherwood, RP Beveridge, JF Daley, H Lane, SF Schlossman, T-cell surface antigens in a patient with blast crisis of chronic myeloid leukemia Blood. ,vol. 61, pp. 640- 644 ,(1983) , 10.1182/BLOOD.V61.4.640.640
MD Minden, TW Mak, The structure of the T cell antigen receptor genes in normal and malignant T cells. Blood. ,vol. 68, pp. 327- 336 ,(1986) , 10.1182/BLOOD.V68.2.327.327
M Gramatzki, CR Bartram, D Muller, M Walter, H Tittelbach, JR Kalden, Early T cell differentiated chronic myeloid leukemia blast crisis with rearrangement of the breakpoint cluster region but not of the T cell receptor beta chain genes. Blood. ,vol. 69, pp. 1082- 1086 ,(1987) , 10.1182/BLOOD.V69.4.1082.1082
E Shtivelman, RP Gale, O Dreazen, A Berrebi, R Zaizov, I Kubonishi, I Miyoshi, E Canaani, bcr-abl RNA in patients with chronic myelogenous leukemia Blood. ,vol. 69, pp. 971- 973 ,(1987) , 10.1182/BLOOD.V69.3.971.971
CR Bartram, A Raghavachar, B Anger, C Stain, P Bettelheim, T lymphocytes lack rearrangement of the bcr gene in Philadelphia chromosome-positive chronic myelocytic leukemia Blood. ,vol. 69, pp. 1682- 1685 ,(1987) , 10.1182/BLOOD.V69.6.1682.1682
M Allouche, A Bourinbaiar, V Georgoulias, R Consolini, A Salvatore, H Auclair, C Jasmin, T Cell Lineage Involvement in Lymphoid Blast Crisis of Chronic Myeloid Leukemia Blood. ,vol. 66, pp. 1155- 1161 ,(1985) , 10.1182/BLOOD.V66.5.1155.1155
TS Ganesan, F Rassool, AP Guo, KH Th'ng, C Dowding, JA Hibbin, BD Young, H White, TO Kumaran, DA Galton, Rearrangement of the bcr Gene in Philadelphia-Chromosome-Negative Chronic Myeloid Leukemia Blood. ,vol. 68, pp. 957- 960 ,(1986) , 10.1007/978-3-642-72624-8_33
LC Chan, AJ Furley, AM Ford, DA Yardumian, MF Greaves, Clonal rearrangement and expression of the T cell receptor beta gene and involvement of the breakpoint cluster region in blast crisis of CGL Blood. ,vol. 67, pp. 533- 536 ,(1986) , 10.1182/BLOOD.V67.2.533.533
Emma Shtivelman, Batia Lifshitz, Robert Peter Gale, Bruce A. Roe, Eli Canaani, Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene Cell. ,vol. 47, pp. 277- 284 ,(1986) , 10.1016/0092-8674(86)90450-2
K.J. ROOZENDAAL, H.J. Reijden, J. P. M. Geraedts, PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKAEMIA WITH T-CELL CHARACTERISTICS British Journal of Haematology. ,vol. 47, pp. 145- 147 ,(1981) , 10.1111/J.1365-2141.1981.TB02768.X