Mast cells: the JEKYLL and HYDE of tumor growth

摘要: Abstract Mast cells accumulate in the stroma surrounding certain tumors, especially mammary adenocarcinoma, and molecules they secrete could benefit tumor. These include heparin, interleukin-8 (IL-8) vascular endothelial cell growth factor (VEGF), which induce neovascularization, histamine, is an immunosuppressant, mitogenic factors, such as platelet-derived (PDGF), nerve GF (NGF), stem-cell (SCF), proteases, disrupt matrix facilitate metastases. By contrast, mast-cell mediators detrimental to tumor cytokines, IL-1, IL-4, IL-6 necrosis factor-α (TNF-α), can apoptosis of cells, tryptase, stimulates protease-activated receptors induces inflammation, chondroitin sulfate, act a decoy inhibit We propose that beneficial destructive are either released from separate granules or much smaller vesicles regulated by selectively distinct signals, tumor-derived oxidized polyamines nitric oxide new cells. This dual role mast be additive infiltrating macrophages, 'polarization' M2 type appears conducive growth.