Amphetamine treatment affects the extra-hypothalamic vasopressinergic system in a sex- and nucleus-dependent manner.
作者： Catalina Ahumada , Carolina Bahamondes , Cledi A Cerda , Roxana A Silva , Gonzalo Cruz
DOI: 10.1111/JNE.12465
关键词:
摘要: The lateral septum (LS), a brain structure implicated in addictive behaviours, regulates the activation of dopaminergic neurones ventral tegmental area. Vasopressinergic projections from extended amygdala to LS, which are sexually dimorphic, could be responsible for vulnerability addiction sex-dependent manner. present study aimed investigate modulatory effects amphetamine (AMPH) on expression vasopressin (AVP) vasopressinergic extra-hypothalamic system sensitised male and female rats. Adult Sprague-Dawley rats underwent an AMPH-locomotor sensitisation protocol. Acute AMPH increased AVP mRNA medial (MeA), whereas AMPH-induced bed nucleus stria terminalis (BNST) only females. Interestingly, increase BNST was higher oestrus females compared dioestrus acute resulted decrease levels males. Thus, there complex region-specific interactions between brain, underlying possible alterations different behaviours caused by chronic exposure.
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