Parallel stochastic simulation of macroscopic calcium currents.

摘要: This work introduces MACACO, a macroscopic calcium currents simulator. It provides parameter-sweep framework which computes Ca2+ from the individual aggregation of unitary currents, using stochastic model for L-type channels. MACACO uses simplified 3-state Markov to simulate response each channel different voltage inputs cell. In order provide an accurate systematic view nature channels, is composed experiment generator, central simulation engine and post-processing script component. Due computational complexity problem dimensions parameter space, employs grid-enabled task farm. Having been designed as biology tool, heavily borrows way cell physiologists conduct report their experimental work.