Iron and Copper Interact during Their Uptake and Deposition in the Brain and other Organs of Developing Rats Exposed to Dietary Excess of the Two Metals

摘要: This study examined the effect of iron and copper loading on rat brain, liver, kidney, femur, blood plasma concentrations these metals transport into organs during development. Dams were fed control diets or iron-loaded (20 g/kg carbonyl iron) with either distilled water copper-loaded (350 mg/L) beginning at d 20 pregnancy. The weanlings also had access to supply 15, 21 63 age. content liver was 17- 30-fold greater in rats than controls, whereas kidney levels generally lower. Iron alone did not increase brain concentrations, suggesting blood-brain barrier is already developed birth. However, dual resulted elevated non-heme 15- 63-d-old compared animals loaded alone. These results suggest that uptake mechanisms may be different when excess present. Liver rats, irrespective status. affected by dietary copper. In copper-containing diet, significantly lower those can decrease organs. It concluded combined supplementation alter metabolism each metal. changes are age organ dependent. Developing very susceptible overload states because significant effects seen early adulthood.